Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

CRISPR-Cas9 gene editing is emerging as a prospective therapy for genomic mutations.
However, current editing approaches are directed primarily toward relatively small cohorts of …

Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key
functions in a wide array of biological systems. While the role of NF-κB in processes, such as …

Regulated necrosis (necroptosis) and apoptosis are crucially involved in severe cardiac
pathological conditions, including myocardial infarction, ischemia-reperfusion injury and …

Background: Inflammation is associated with cardiac remodeling and heart failure, but how it
is initiated in response to nonischemic interventions in the absence of cell death is not …

Background: CaMKII (Ca2+/calmodulin-dependent kinase II) plays a central role in cardiac
ischemia/reperfusion (I/R) injury—an important therapeutic target for ischemic heart disease …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …