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[HTML][HTML] Monocarboxylate transporters in cancer
Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics?
As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …
causing an excess production of lactate along with an increase in extracellular acidity …
Glucose metabolism and glucose transporters in breast cancer
E Shin, JS Koo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …
high mortality rates despite the continuously advancing treatment strategies. Glucose is …
Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
L Wilde, M Roche, M Domingo-Vidal, K Tanson… - Seminars in …, 2017 - Elsevier
abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
[HTML][HTML] Targeting glucose metabolism to overcome resistance to anticancer chemotherapy in breast cancer
Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …
distinct phenotypical and morphological characteristics. These are based on their gene …
MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p
A Affinito, C Quintavalle, RV Chianese… - Cell death …, 2024 - nature.com
Multiple oncogenic alterations contribute to breast cancer development. Metabolic
reprogramming, deeply contributing to tumor microenvironment (TME) education, is now …
reprogramming, deeply contributing to tumor microenvironment (TME) education, is now …
Clinical and functional relevance of the monocarboxylate transporter family in disease pathophysiology and drug therapy
The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for
monocarboxylate transporters (MCTs), which mediate the absorption and distribution of …
monocarboxylate transporters (MCTs), which mediate the absorption and distribution of …
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive neoplasia lacking
the expression of hormonal receptors and human epidermal growth factor receptor-2 …
the expression of hormonal receptors and human epidermal growth factor receptor-2 …
Local production of lactate, ribose phosphate, and amino acids by human triple-negative breast cancer
Background Upregulated glucose metabolism is a common feature of tumors. Glucose can
be broken down by either glycolysis or the oxidative pentose phosphate pathway (oxPPP) …
be broken down by either glycolysis or the oxidative pentose phosphate pathway (oxPPP) …
Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice
H Li, Y Huang, DQ Jiang, LZ Cui, Z He, C Wang… - Cell death & …, 2018 - nature.com
Effective control of non-small-cell lung cancer (NSCLC) remains clinically challenging,
especially during advanced stages of the disease. This study developed an adoptive T-cell …
especially during advanced stages of the disease. This study developed an adoptive T-cell …