While normal B-and T-lymphocytes require antigenic ligands to become activated via their B-
and T-cell receptors (BCR and TCR, respectively), B-and T-cell lymphomas show the broad …

Mantle cell lymphoma (MCL) is an uncommon mature B cell lymphoma which presents a
clinical spectrum ranging from indolent to aggressive disease, with challenges in disease …

The bromodomain and extraterminal domain (BET) family proteins serve as primary readers
of acetylated lysine residues and play crucial roles in cell proliferation and differentiation …

Acute myeloid leukemia (AML) is an invasive hematopoietic malignancy requiring novel
treatment strategies. In this study, we identified phosphodiesterase 3 A (PDE3A) as a …

The use of Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib achieves a remarkable
clinical response in mantle cell lymphoma (MCL). Acquired drug resistance, however, is …

Background Distinctive heterogeneity characterizes diffuse large B‐cell lymphoma (DLBCL),
one of the most frequent types of non‐Hodgkin's lymphoma. Mitochondria have been …

The pro-tumorigenic or anti-tumorigenic role of tumor infiltrating mast cells (TIMs) in tumors
depends not only on the type of cancer and the degree of tumor progression, but also on …

Polycystic ovary syndrome (PCOS) is the predominant cause of subfertility in reproductive-
aged women; however, its pathophysiology remains unknown. Neurotensin (NTS) is a …

Background Clear cell renal carcinoma (ccRCC), the leading histological subtype of RCC,
lacks any targeted therapy options. Although some studies have shown that early growth …

Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body,
including the oral cavity. Under certain predisposing conditions, C. albicans invades …