Mesenchymal stem cells, bioactive factors, and scaffolds in bone repair: from research perspectives to clinical practice

S Stamnitz, A Klimczak - Cells, 2021 - mdpi.com
Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration.
However, tracking cells and maintaining them in the site of injury is difficult. A potential …

Hydrogels for large-scale expansion of stem cells

S Yin, Y Cao - Acta biomaterialia, 2021 - Elsevier
Stem cells demonstrate considerable promise for various preclinical and clinical
applications, including drug screening, disease treatments, and regenerative medicine …

Bone tissue engineering using osteogenic cells: from the bench to the clinical application

JA Shibli, BE Nagay, LJ Suárez… - … Engineering Part C …, 2022 - liebertpub.com
The use of tissue engineering to restore and to build new bone tissue is under active
research at present. The following review summarizes the latest studies and clinical trials …

MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment

J Yang, J Shuai, L Siow, J Lu, M Sun, W An, M Yu… - Bone Research, 2024 - nature.com
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory
microenvironment remains a challenge, as chronic local inflammation can largely impair …

Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the TGF‑β/Smad3 pathway

Y Huang, L Liao, H Su, X Chen… - Experimental and …, 2021 - spandidos-publications.com
Psoralen, one of the active ingredients in Psoralea corylifolia, has been previously reported
to regulate the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) …

[HTML][HTML] Plant molecules reinforce bone repair: Novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects

Y Chen, W Gan, Z Cheng, A Zhang, P Shi, Y Zhang - Materials Today Bio, 2024 - Elsevier
Bone defects have become a major cause of disability and death. To overcome the
limitations of natural bone implants, including donor shortages and immune rejection risks …

Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration

Y Niu, Z Yang, Y Yang, X Wang, P Zhang, L Lv… - NPJ Regenerative …, 2023 - nature.com
Recruiting endogenous stem cells to bone defects without stem cell transplantation and
exogenous factor delivery represents a promising strategy for bone regeneration. Herein, we …

[HTML][HTML] Aptamer-functionalized hydrogels promote bone healing by selectively recruiting endogenous bone marrow mesenchymal stem cells

JS Gong, GQ Zhu, Y Zhang, B Chen, YW Liu, HM Li… - Materials Today Bio, 2023 - Elsevier
Bone regeneration heavily relies on bone marrow mesenchymal stem cells (BMSCs).
However, recruiting endogenous BMSCs for in situ bone regeneration remains challenging …