Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

Signaling pathways are critical modulators of a variety of physiological and pathological
processes, and the abnormal activation of some signaling pathways can contribute to …

Huntington's disease (HD) is a dominantly inherited progressive neurological disease
characterized by chorea, an involuntary brief movement that tends to flow between body …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

Recent studies have identified impairments in neural induction and in striatal and cortical
neurogenesis in Huntington's disease (HD) knock-in mouse models and associated …

Background Alzheimer's disease (AD) pathology occurs in part as the result of excessive
production of β-amyloid (Aβ). Metabotropic glutamate receptor 5 (mGluR5) is now …

Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to
activation of a wide variety of signalling pathways. mGluRs couple to Gαq/11 proteins …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Neurodegenerative diseases are pathological conditions that have an insidious onset and
chronic progression. Different models have been established to study these diseases in …

Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous
system toxicity of MA is well documented. The mechanisms contributing to this toxicity have …