The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

HIV forms spherical, membrane-enveloped, pleomorphic virions, 1,000–1,500 Å in diameter,
which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles …

HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that
this entry proceeds through nuclear pore complexes (NPCs), with the 120× 60 nm capsid …

HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier
of the nuclear pore complex and deliver the genome directly into the nucleus,. Remarkably …

The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-
acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby …

Abstract A short, 14-amino-acid segment called SP1, located in the Gag structural protein,
has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the …

HIV-1 contains a cone-shaped capsid encasing the viral genome. This capsid is thought to
follow fullerene geometry—a curved hexameric lattice of the capsid protein, CA, closed by …

Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans,
only one, leading to human immunodeficiency virus (HIV) type 1 (M) has become pandemic …

Summary HIV-1 reverse transcription (RT) occurs before or during uncoating, but the cellular
compartment where RT and uncoating occurs is unknown. Using imaging and biochemical …

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However …