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Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
Novel therapeutic strategies for dementia
R Cacabelos, C Torrellas, I Carrera… - CNS & Neurological …, 2016 - ingentaconnect.com
Dementia represents a major problem of health and disability, with a relevant economic
impact on our society. Despite important advances in pathogenesis, diagnosis and …
impact on our society. Despite important advances in pathogenesis, diagnosis and …
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
A new group of compounds, promising for the design of original multitarget therapeutic
agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane …
agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane …
Hydrazides and hydrazones: Robust scaffolds in neurological and neurodegenerative disorders
Background: Hydrazides and hydrazones are found in a variety of bioactive compounds that
have a wide range of pharmacological applications. There have been significant …
have a wide range of pharmacological applications. There have been significant …
Synthesis, biological assessment and molecular docking study of new sulfur-linked 1, 2, 4-triazole and 1, 2, 3-triazole hybrid derivatives as potential DNA gyrase …
A series of new pyridine-1, 2, 4-triazole-tagged 1, 2, 3-triazole hybrid molecules were
obtained. The new compounds were synthesized via click chemistry of 1, 2, 4-triazole-3 …
obtained. The new compounds were synthesized via click chemistry of 1, 2, 4-triazole-3 …
[HTML][HTML] Chalcone scaffolds exhibiting acetylcholinesterase enzyme inhibition: Mechanistic and computational investigations
This study was aimed to perform the mechanistic investigations of chalcone scaffold as
inhibitors of acetylcholinesterase (AChE) enzyme using molecular docking and molecular …
inhibitors of acetylcholinesterase (AChE) enzyme using molecular docking and molecular …
[HTML][HTML] Synthesis, characterization and biological evaluation of metal adamantyl 2-pyridylhydrazone complexes
Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu
(II)(1), Co (II)(2), Ni (II)(3) and Zn (II)(4), have been synthesized and characterized using …
(II)(1), Co (II)(2), Ni (II)(3) and Zn (II)(4), have been synthesized and characterized using …
Novel iodinated hydrazide-hydrazones and their analogues as acetyl-and butyrylcholinesterase Inhibitors
M Krátký, Š Štěpánková, M Brablíková… - Current Topics in …, 2020 - benthamdirect.com
Background: Hydrazide-hydrazones have been known as scaffold with various biological
activities including inhibition of acetyl-(AChE) and butyrylcholinesterase (BuChE) …
activities including inhibition of acetyl-(AChE) and butyrylcholinesterase (BuChE) …
Synthesis, characterization, crystal structure, and DFT study of a new square planar Cu (II) complex containing bulky adamantane ligand
A copper complex with square planar geometry,[(L) CuBr2](1),(L= N′-(furan-2-ylmethylene)
adamantne-1-carbohydrazide) has been synthesized and characterized by Fourier transfer …
adamantne-1-carbohydrazide) has been synthesized and characterized by Fourier transfer …
Design, synthesis and antimicrobial assessments of aminoacetylenic-piperazine nitroimidazole hybrid compounds
A new series of aminoacetylenic nitroimidazole piperazine hybrid compounds were
prepared via three-component reaction. Mannich-type reaction was utilized to couple the …
prepared via three-component reaction. Mannich-type reaction was utilized to couple the …