Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Spermatogenesis is an extremely active replicative process capable of generating approxi
mately 1,000 sperm a second. The high rates of cell division inherent in this process imply …

The link between varicoceles and male infertility has been a matter of debate for more than
half a century. Varicocele is considered the most common correctable cause of male …

Background Present knowledge on the impact of varicoceles on testicular function is largely
based on studies of subfertile and infertile men, making it difficult to extrapolate the impact of …

Infertility affects over 6 million couples in the United States. Half of these couples have a
component of male factor infertility and almost 30% solely are caused by a male factor [1]. In …

BACKGROUND: The pathophysiology of the testicular damage in varicocele has not been
completely understood. Oxidative stress and related sperm DNA damage have been …

OBJECTIVE: To examine levels of sperm DNA damage and oxidative stress (OS) in infertile
men with varicocele. DESIGN: Prospective controlled study. SETTING: Male infertility clinic …

Varicocele, or dilation of the pampiniform venous plexus, affects up to 15% of men.
However, few of these men encounter problems with fertility. This discrepancy between men …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Defective sperm function is the most common cause of infertility, and until recently, was
difficult to evaluate and treat. Mammalian spermatozoa membranes are rich in poly …