Low-intensity ultrasound neuromodulation: an overview of mechanisms and emerging human applications

A Fomenko, C Neudorfer, RF Dallapiazza, SK Kalia… - Brain stimulation, 2018 - Elsevier
Background There is an emerging need for noninvasive neuromodulation techniques to
improve patient outcomes while minimizing adverse events and morbidity. Low-intensity …

Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism

T Sato, MG Shapiro, DY Tsao - Neuron, 2018 - cell.com
Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates

AN Pouliopoulos, N Kwon, G Jensen, A Meaney… - Scientific reports, 2021 - nature.com
An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …

[HTML][HTML] Combining brain perturbation and neuroimaging in non-human primates

PC Klink, JF Aubry, VP Ferrera, AS Fox… - NeuroImage, 2021 - Elsevier
Brain perturbation studies allow detailed causal inferences of behavioral and neural
processes. Because the combination of brain perturbation methods and neural …

[HTML][HTML] Long term study of motivational and cognitive effects of low-intensity focused ultrasound neuromodulation in the dorsal striatum of nonhuman primates

F Munoz, A Meaney, A Gross, K Liu, AN Pouliopoulos… - Brain stimulation, 2022 - Elsevier
Noninvasive brain stimulation using transcranial focused ultrasound (FUS) has many
potential applications as a research and clinical tool, including incorporation into neural …

[HTML][HTML] Noninvasive ultrasound retinal stimulation for vision restoration at high spatiotemporal resolution

B ThomasBiju, SK Kirk - BME frontiers, 2022 - spj.science.org
Objective. Retinal degeneration involving progressive deterioration and loss of function of
photoreceptors is a major cause of permanent vision loss worldwide. Strategies to treat …

Low intensity focused ultrasound for epilepsy—a new approach to neuromodulation

EJ Bubrick, NJ McDannold, PJ White - Epilepsy Currents, 2022 - journals.sagepub.com
Patients with drug-resistant epilepsy (DRE) who are not surgical candidates have
unacceptably few treatment options. Benefits of implanted electrostimulatory devices are still …

Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson's disease mouse model

R Ji, M Smith, Y Niimi, ME Karakatsani, MF Murillo… - Scientific Reports, 2019 - nature.com
Focused ultrasound-enhanced intranasal (IN+ FUS) delivery is a noninvasive approach that
utilizes the olfactory pathway to administer pharmacological agents directly to the brain …

Therapeutic potentials of localized blood–brain barrier disruption by noninvasive transcranial focused ultrasound: A technical review

A Cammalleri, P Croce, W Lee, K Yoon… - Journal of Clinical …, 2020 - journals.lww.com
The demands for region-specific, noninvasive therapies for neurologic/psychiatric conditions
are growing. The rise of transcranial focused ultrasound technology has witnessed …