Menthol is an important flavoring additive that triggers a cooling sensation. Under
physiological condition, low to moderate concentrations of menthol activate transient …

The Q 10 temperature coefficient, which is widely used in scientific literature, is a measure of
the temperature sensitivity of chemical reaction rates or biological processes. However, the …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

Menthol in mints elicits coolness sensation by selective activation of TRPM8 ion channel.
Although structures of TRPM8 channel were determined by cryo-EM in the apo and liganded …

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …

Temperature sensing is one of the oldest capabilities of living organisms, and is essential for
sustaining life, because failure to avoid extreme noxious temperatures can result in tissue …

The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …

Although acute itch has a protective role by removing irritants to avoid further damage,
chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a …

Conspectus Transmembrane proteins located within biological membranes play a crucial
role in a variety of important cellular processes, such as energy conversion and signal …

Transient receptor potential melastatin 8 (TRPM8) is a temperature-and menthol-sensitive
ion channel that contributes to diverse physiological roles, including cold sensing and pain …