Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Cancer is often considered a genetic disease. However, much of the enormous plasticity of
cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …

Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

The circadian clock controls several aspects of mammalian physiology and orchestrates the
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …

The circadian timing system (CTS) controls several critical molecular pathways for cancer
processes and treatment effects over the 24 hours, including drug metabolism, cell cycle …

Dosing time accounts for a large variability in efficacy and/or toxicity for many drugs.
Therefore, chronotherapy has been shown to effectively improve drug efficacy and to reduce …

The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and
animals show profound annual cycles in physiology, health, morphology, behaviour and …

Circadian clock genes regulate cancer development and chemotherapy susceptibility.
Accordingly, chronotherapy based on circadian phenotypes might be applied to improve …