Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic
Parkinson's disease (PD). Therapies based on PQ's presumed mechanisms of action have …

Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of
patients with Alzheimer's and related dementias and cancer patients after chemo-or radio …

Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss
of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of …

Astrocytes are the largest group of glial cells in the brain and participate in several essential
functions of the central nervous system (CNS). Disruption of their normal physiological …

A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

As the most abundant cell types in the brain, astrocytes form a tissue-wide signaling network
that is responsible for maintaining brain homeostasis and regulating various brain activities …

Senescent astrocytes accumulate with aging and contribute to brain dysfunction and
diseases such as Alzheimer's disease (AD), however, the mechanisms underlying the …