Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

Genomics and epidemiology of the P. 1 SARS-CoV-2 lineage in Manaus, Brazil

NR Faria, TA Mellan, C Whittaker, IM Claro… - Science, 2021 - science.org
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome …

Sensitivity of SARS-CoV-2 B. 1.1. 7 to mRNA vaccine-elicited antibodies

DA Collier, A De Marco, IATM Ferreira, B Meng… - Nature, 2021 - nature.com
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is
compounded in some areas by the higher transmission potential of the B. 1.1. 7 variant …

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

L Zhang, CB Jackson, H Mou, A Ojha, H Peng… - Nature …, 2020 - nature.com
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally.
We therefore compare the properties of the mutated S protein (SG614) with the original …

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

C Tschöpe, E Ammirati, B Bozkurt, ALP Caforio… - Nature reviews …, 2021 - nature.com
Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the
myocardium and a high risk of deteriorating cardiac function, has a heterogeneous …

Ecology, evolution and spillover of coronaviruses from bats

M Ruiz-Aravena, C McKee, A Gamble, T Lunn… - Nature Reviews …, 2022 - nature.com
In the past two decades, three coronaviruses with ancestral origins in bats have emerged
and caused widespread outbreaks in humans, including severe acute respiratory syndrome …

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

MI Barton, SA MacGowan, MA Kutuzov, O Dushek… - Elife, 2021 - elifesciences.org
The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain
(RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in …

COVID-19 pandemic and mental health consequences: Systematic review of the current evidence

N Vindegaard, ME Benros - Brain, behavior, and immunity, 2020 - Elsevier
Background During the COVID-19 pandemic general medical complications have received
the most attention, whereas only few studies address the potential direct effect on mental …

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

TN Starr, AJ Greaney, SK Hilton, D Ellis, KHD Crawford… - cell, 2020 - cell.com
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …