MLL1, located on human chromosome 11, is disrupted in distinct recurrent chromosomal
translocations in several leukemia subsets. Studying the MLL1 gene and its oncogenic …

Abstract The PAX-SIX-EYA-DACH network (PSEDN) is a central developmental
transcriptional regulatory network from Drosophila to humans. The PSEDN is comprised of …

Epithelial–mesenchymal transition (EMT) has a major role in cancer progression and
metastasis. However, the specific mechanism of transcriptional repression involved in this …

RNA-binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are
found to be dysregulated in hematological malignancies. Here we identify the RBP RNA …

A classical view of blood cell development is that multipotent hematopoietic stem and
progenitor cells (HSPCs) become lineage-restricted at defined stages. Lin− c-Kit+ Sca-1+ …

PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is one of the
most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia …

Acute myeloid leukemia (AML) is a highly heterogeneous disease with regard to biological
characteristics and receptor expression. Toll-like receptors (TLRs) are upstream to the …

Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and
finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as …

Dysregulated apoptosis and proliferation are fundamental properties of cancer, and
microRNAs (miRNA) are critical regulators of these processes. Loss of miR-15a/16-1 at …

Background Biological processes are controlled by transcription networks. Expression
changes of transcription factor (TF) genes in precancerous lesions are therefore crucial …