Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing

J Chadha, K Harjai, S Chhibber - Environmental microbiology, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

Pseudomonas aeruginosa biofilms and their partners in crime

MM Cendra Gascón… - Biotechnology …, 2021 - upcommons.upc.edu
Pseudomonas aeruginosa biofilms and the capacity of the bacterium to coexist and interact
with a broad range of microorganisms have a substantial clinical impact. This review focuses …

Extracellular DNA promotes efficient extracellular electron transfer by pyocyanin in Pseudomonas aeruginosa biofilms

SH Saunders, CM Edmund, MD Yates, FJ Otero… - Cell, 2020 - cell.com
Redox cycling of extracellular electron shuttles can enable the metabolic activity of
subpopulations within multicellular bacterial biofilms that lack direct access to electron …

Pseudomonas aeruginosa reference strains PAO1 and PA14: A genomic, phenotypic, and therapeutic review

A Grace, R Sahu, DR Owen, VA Dennis - Frontiers in Microbiology, 2022 - frontiersin.org
Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been
recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of …

Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa

S Hall, C McDermott, S Anoopkumar-Dukie… - Toxins, 2016 - mdpi.com
Pyocyanin has recently emerged as an important virulence factor produced by
Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a …

Pseudomonas aeruginosa's greenish-blue pigment pyocyanin: its production and biological activities

AA Abdelaziz, AMA Kamer, KB Al-Monofy… - Microbial Cell …, 2023 - Springer
A subject of great interest is the bioprospecting of microorganisms and their bioactive
byproducts, such as pigments. Microbial pigments have various benefits, including being …

No Correlation between Biofilm Formation, Virulence Factors, and Antibiotic Resistance in Pseudomonas aeruginosa: Results from a Laboratory-Based In Vitro Study

M Gajdács, Z Baráth, K Kárpáti, D Szabó, D Usai… - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) possesses a plethora of virulence determinants,
including the production of biofilm, pigments, exotoxins, proteases, flagella, and secretion …

An overview of biofilm formation–combating strategies and mechanisms of action of antibiofilm agents

ST Asma, K Imre, A Morar, V Herman, U Acaroz… - Life, 2022 - mdpi.com
Biofilm formation on surfaces via microbial colonization causes infections and has become a
major health issue globally. The biofilm lifestyle provides resistance to environmental …

Natural products as inspiration for the development of bacterial antibiofilm agents

RJ Melander, AK Basak, C Melander - Natural product reports, 2020 - pubs.rsc.org
Natural products have historically been a rich source of diverse chemical matter with
numerous biological activities, and have played an important role in drug discovery in many …