Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution,
yet it has mostly been used as a superficial metaphor because we know little about its …

In recent years, scientists have realized that evolution can occur on timescales much shorter
than the" long lapse of ages" emphasized by Darwin—in fact, evolutionary change is …

To what extent is the convergent evolution of protein function attributable to convergent or
parallel changes at the amino acid level? The mutations that contribute to adaptive protein …

Epistasis has substantial impacts on evolution, in particular, the rate of adaptation. We
generated combinations of beneficial mutations that arose in a lineage during rapid …

By formalizing the relationship between genotype or phenotype and fitness, fitness
landscapes harbor information on molecular and evolutionary constraints. The shape of the …

The accumulation of data on the genomic bases of adaptation has triggered renewed
interest in theoretical models of adaptation. Among these models, Fisher's geometric model …

Many multicellular eukaryotes have reasonably high per-generation mutation rates.
Consequently, most populations harbor an abundance of segregating deleterious alleles …

Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …

Distributions of mutation fitness effects from evolution experiments are available in an
increasing number of species, opening the way for a vast array of applications in …