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[HTML][HTML] The metabolic fates of pyruvate in normal and neoplastic cells
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …
Regulation of normal and neoplastic proliferation and metabolism by the extended Myc network
The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors,
regulates many hundreds to thousands of genes involved in proliferation, energy …
regulates many hundreds to thousands of genes involved in proliferation, energy …
Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation
MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …
Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development
Abstract The Carbohydrate Response Element (ChoRE) Binding Protein (ChREBP) and its
binding partner Max-like protein X (MLX) mediate transcription of lipogenic genes under …
binding partner Max-like protein X (MLX) mediate transcription of lipogenic genes under …
AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes
Malaria, caused by Plasmodium parasites is a severe disease affecting millions of people
around the world. Plasmodium undergoes obligatory development and replication in the …
around the world. Plasmodium undergoes obligatory development and replication in the …
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis
Carbohydrate response element–binding protein (ChREBP) is a carbohydrate-sensing
transcription factor that regulates both adaptive and maladaptive genomic responses in …
transcription factor that regulates both adaptive and maladaptive genomic responses in …
Inherently reduced expression of ASC restricts caspase-1 processing in hepatocytes and promotes Plasmodium infection
Inflammasome-mediated caspase-1 activation facilitates innate immune control of
Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria …
Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria …
RNA-Seq transcriptome profiling in three liver regeneration models in rats: comparative analysis of partial hepatectomy, ALLPS, and PVL
The liver is a unique organ that has a phenomenal capacity to regenerate after injury.
Different surgical procedures, including partial hepatectomy (PH), intraoperative portal vein …
Different surgical procedures, including partial hepatectomy (PH), intraoperative portal vein …
Lessons in aging from Myc knockout mouse models
Despite MYC being among the most intensively studied oncogenes, its role in normal
development has not been determined as Myc−/− mice do not survival beyond mid …
development has not been determined as Myc−/− mice do not survival beyond mid …
[HTML][HTML] Coordinated cross-talk between the myc and mlx networks in liver regeneration and neoplasia
Background & Aims The c-Myc (Myc) Basic helix-loop-helix leucine zipper (bHLH-ZIP)
transcription factor is deregulated in most cancers. In association with Max, Myc controls …
transcription factor is deregulated in most cancers. In association with Max, Myc controls …