Multiple cell-signalling pathways converge on chromatin to induce gene expression
programmes. The inducible transcriptional programmes that are established as a result of …

Wired neurons form new presynaptic boutons in response to increased synaptic activity,
however the mechanism (s) by which this occurs remains uncertain. Drosophila motor …

Depolarization-induced signaling to the nucleus by the L-type voltage-gated calcium
channel Cav1. 2 is widely assumed to proceed by elevating intracellular calcium. The …

More than 98% of the human genome is made up of non-coding DNA, but techniques to
ascertain its contribution to human disease have lagged far behind our understanding of …

We examined the effects of altered extracellular potassium concentration on the output of the
well-studied pyloric circuit in the crab, Cancer borealis. Pyloric neurons initially become …

Elevated potassium concentration ([K+]) is often used to alter excitability in neurons and
networks by shifting the potassium equilibrium potential (EK) and, consequently, the resting …

Neuropathic pain (NP) is associated with profound gene expression alterations within the
nociceptive system. DNA mechanisms, such as epigenetic remodeling and repair pathways …

Neural circuits must both function reliably and flexibly adapt to changes in their environment.
We studied how both biological neurons and computational models respond to high …

The crustacean stomatogastric ganglion (STG) is a relatively simple central pattern
generator that produces two well-studied robust rhythmic motor patterns in the absence of …

Multicellular organisms are composed of different tissues and cells that interact with each
other in a coordinated and synchronized way in order to maintain homeostasis. The …