Factors influencing venous remodeling in the development of varicose veins of the lower limbs

L Gwozdzinski, A Pieniazek, K Gwozdzinski - International Journal of …, 2024 - mdpi.com
One of the early symptoms of chronic venous disease (CVD) is varicose veins (VV) of the
lower limbs. There are many etiological environmental factors influencing the development …

Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis

Y Shi, C Wu, J Shi, T Gao, H Ma, L Li, Y Zhao - European Journal of …, 2024 - Elsevier
Necroptosis is a pivotal contributor to the pathogenesis of various human diseases,
including those affecting the nervous system, cardiovascular system, pulmonary system, and …

Protective effects of esculetin against doxorubicin‐induced toxicity correlated with oxidative stress in rat liver: in vivo and in silico studies

Z Köroğlu, D Kizir, M Karaman, Y Demir… - … of Biochemical and …, 2024 - Wiley Online Library
Doxorubicin (DOX) is widely used in cancer treatment but the dose‐related toxicity of DOX
on organs including the liver limit its use. Therefore, there is great interest in combining DOX …

Coumarin hybrids: a sighting of their roles in drug targeting

NM Zeki, YF Mustafa - Chemical Papers, 2024 - Springer
Phytocoumarins exhibit a range of biological activities, including antibacterial, anti-
inflammatory, antiradical, oncolytic, and reduction of monoamine oxidase B effects. These …

Inhibitory mechanism of esculetin on tyrosinase and browning of fresh-cut apple: new perspectives

LJ Wang, QH Bai, QX Pan, YF Wu, TT Shao… - Postharvest Biology and …, 2024 - Elsevier
The anti-tyrosinase mechanism of esculetin has been systematically investigated by various
spectroscopic techniques and molecular simulation. And the outcomes confirmed that …

Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for …

EM Radwan, E Abo-Elabass, AE Abd El-Baky… - Frontiers in …, 2023 - frontiersin.org
Being the sixth most diagnosed cancer and the fourth leading cause of cancer-related
deaths worldwide, liver cancer is considered as a serious disease with a high prevalence …

Induction of ferroptosis by natural phenols: a promising strategy for cancer therapy

Y Zhang, J **e - Phytotherapy Research, 2024 - Wiley Online Library
In recent years, heightened interest surrounds the exploration of natural phenols as potential
agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated …

[HTML][HTML] The coumarin-derivative esculetin protects against lipotoxicity in primary rat hepatocytes via attenuating JNK-mediated oxidative stress and attenuates free …

M **a, Z Wu, J Wang, M Buist-Homan, H Moshage - Antioxidants, 2023 - mdpi.com
Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-
associated fatty liver disease (MAFLD). However, the mechanisms underlying their …

Protective effects of esculetin against ovary ischemia–reperfusion injury model in rats

M Güvenç, M Yüksel, T Kutlu, M Etyemez… - … of Biochemical and …, 2024 - Wiley Online Library
Aims Ovarian ischemia–reperfusion (I/R) injury is a phenomenon that necessitates urgent
intervention, which occurs as a result of ovarian torsion, and it is frequently seen in young …

Unravelling the metabolomic pool of Ocimum microgreens under diverse growing conditions through targeted compound analysis and non-targeted UHPLC-QToF …

A Kumar, N Singh, R Joshi - Food Bioscience, 2024 - Elsevier
Abstract Ocimum Sanctum L.(Basil) is a perennial herb belonging to the Lamiaceae family.
The composition of microgreens is influenced by environmental conditions. Consequently …