The role of miRNAs in liver diseases: Potential therapeutic and clinical applications

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …

The role of miRNAs in insulin resistance and diabetic macrovascular complications–A review

SSA Mageed, AS Doghish, A Ismail… - International journal of …, 2023 - Elsevier
Diabetes is the most prevalent metabolic disturbance disease and has been regarded
globally as one of the principal causes of mortality. Diabetes is accompanied by several …

miRNAs insights into rheumatoid arthritis: Favorable and detrimental aspects of key performers

AS Doghish, A Ismail, HA El-Mahdy, SY Elkhawaga… - Life Sciences, 2023 - Elsevier
Rheumatoid arthritis (RA) is a severe autoimmune inflammation that mostly affects the joints.
It's a multifactorial disease. Its clinical picture depends on genetic and epigenetic factors …

miRNAs as cornerstones in adipogenesis and obesity

SY Elkhawaga, A Ismail, EGE Elsakka, AS Doghish… - Life Sciences, 2023 - Elsevier
In recent decades, obesity has extensively emerged to the level of pandemics. It's
significantly associated with serious co-morbidities that could decrease life quality and even …

miRNAs role in bladder cancer pathogenesis and targeted therapy: signaling pathways interplay–a review

HA El-Mahdy, EGE Elsakka, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Bladder cancer (BC) is the 11th most popular cancer in females and 4th in males. A lot of
efforts have been exerted to improve BC patients' care. Besides, new approaches have …

miRNAs role in cervical cancer pathogenesis and targeted therapy: Signaling pathways interplay

AS Doghish, MA Ali, SS Elyan, MA Elrebehy… - … -Research and Practice, 2023 - Elsevier
Cervical cancer (CC) is the primary cause of cancer deaths in underdeveloped countries.
The persistence of infection with high-risk human papillomavirus (HPV) is a significant …

miRNAs role in glioblastoma pathogenesis and targeted therapy: Signaling pathways interplay

SS Elshaer, AI Abulsoud, D Fathi… - … -Research and Practice, 2023 - Elsevier
High mortality and morbidity rates and variable clinical behavior are hallmarks of
glioblastoma (GBM), the most common and aggressive primary malignant brain tumor …

miRNAs as cornerstones in diabetic microvascular complications

A Ismail, HA El-Mahdy, MG Eldeib… - Molecular Genetics and …, 2023 - Elsevier
Diabetes mellitus is usually accompanied by nephropathy, retinopathy, and neuropathy as
microvascular complications. MicroRNAs (miRNAs) can affect the kidney, retina, and …

An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer

D Fathi, MS Elballal, AE Elesawy, AI Abulsoud… - Life Sciences, 2023 - Elsevier
Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …

miRNAs as potential game-changers in melanoma: a comprehensive review

GM Abd-Allah, A Ismail, HA El-Mahdy… - … -Research and Practice, 2023 - Elsevier
Melanoma is the sixth most frequent malignancy. It represents 1.7% of all cancer cases
worldwide. Many risk factors are associated with melanoma including ultraviolet radiation …