Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Fraxetin is a bioactive molecule present in various natural plants, especially Cortex Fraxini.
Evidenced outcomes in phytochemical and biological analyses for this agent are now …

Doxorubicin (DOX) has been recognized as one of the most effective chemotherapies and
extensively used in the clinical settings of human cancer. However, DOX-mediated …

Ferroptosis is an iron-dependent cell death and contributes to doxorubicin-induced
cardiotoxicity, but the mechanisms behind intracellular iron overload in cardiomyocyte after …

Anthracyclines are essential adjuvant therapies for a variety of cancers, particularly breast,
gastric and esophageal cancers. Whilst prolonging cancer-related survival, these agents …

The current study was conducted to determine the precise mechanisms of Sirtuin-1 (Sirt-1),
TGF-β (Transforming Growth Factor-β), and long non-coding RNA Metastasis Associated …

Background Anthracycline-mediated adverse cardiovascular events are among the leading
causes of morbidity and mortality in patients with cancer. Sodium-glucose cotransporter 2 …

Objectives Doxorubicin (DOX) is a chemotherapy drug for treating malignant tumours.
However, its cardiotoxicity has limited its clinical application. The Radix Aconiti Lateralis …

Fraxetin, a natural compound extracted from the Chinese herb Cortex Fraxini, is reported to
boast extensive antitumor properties in various cancers. However, whether fraxetin exhibited …

Doxorubicin (DOX) is a widely used chemotherapy drug that can cause significant
cardiotoxicity, limiting its clinical application. This study aimed to investigate the potential …