Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning,
vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing …

Oculocutaneous albinism is an autosomal recessive disease caused by the complete
absence or decrease of melanin biosynthesis in melanocytes. Due to the reduction or …

Importance Disability secondary to skin conditions is substantial worldwide. The Global
Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to …

Epidemiological studies point to race as a determining factor in cancer susceptibility. In US
registries recording cancer incidence and survival by race (distinguishing 'black versus …

Albinism describes a heterogeneous group of genetically determined disorders
characterized by disrupted synthesis of melanin and a range of developmental ocular …

Albinism is a group of rare inherited disorders arising from impairment of melanin
biosynthesis. The reduction of melanin synthesis leads to hypopigmentation of the skin and …

Albinism, typically characterized by decreased melanin synthesis, is associated with
significant visual deficits owing to developmental changes during neurosensory retina …

BACKGROUND. Oculocutaneous albinism (OCA) results in reduced melanin synthesis, skin
hypopigmentation, increased risk of UV-induced malignancy, and developmental eye …

Albinism is a worldwide genetic disorder caused by mutations in at least 20 genes, identified
to date, that affect melanin production or transport in the skin, hair and eyes. Patients present …

Methods We conducted qualitative semistructured interviews of PWA in Botswana.
Participants were selected by convenience sampling from a larger cohort of 50 PWA older …