Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

After decades of slow progress, the last years have seen a rapid acceleration of the
development of adjuvanted vaccines which have lately been approved for human use …

In the last decade there have been some significant advances in vaccine adjuvants,
particularly in relation to their inclusion in licensed products. This was proceeded by several …

Engineering vaccine-based therapeutics for infectious diseases is highly challenging, as
trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically …

Influenza is a major cause of respiratory disease leading to hospitalization in young
children. However, seasonal trivalent influenza vaccines (TIVs) have been shown to be …

Squalene is a natural linear triterpene that can be found in high amounts in certain fish liver
oils, especially from deep-sea sharks, and to a lesser extent in a wide variety of vegeTable …

Natural killer (NK) cells are among the most important innate immunity members, which are
the first cells that fight against infected cells. The function of these cells is impaired in …

Vaccination serves as a cornerstone of global health. Successful prevention of infection or
disease by vaccines is achieved through elicitation of pathogen-specific antibodies and long …

To gain insight into how an adjuvant impacts vaccination responses, we use systems
immunology to study human H5N1 influenza vaccination with or without the adjuvant AS03 …

Systems vaccinology has proven a fascinating development in the last decade. Where
traditionally vaccine development has been dominated by trial and error, systems …