Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic
cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

Background: It is increasingly recognized that gut microbiota play a pivotal role in the
development of atherosclerotic cardiovascular disease. Previously, we have reported that …

Lymphatic vessels collect interstitial fluid that has extravasated from blood vessels and
return it to the circulatory system. Another important function of the lymphatic network is to …

Dendritic cells (DCs) mediate tolerance to food antigens, limit reactivity to the gut microbiota
and are required for optimal response to intestinal pathogens. Intestinal DCs are …

Summary Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and
sensed by most hematopoietic cells. Genome-wide association studies and experimental …

While conventional pathogenic protists have been extensively studied, there is an
underappreciated constitutive protist microbiota that is an integral part of the vertebrate …

Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …

Gut microbiota, specifically gut bacteria, are critical for effective immune checkpoint
blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment …