Lactoferrin: Structure, function, denaturation and digestion

B Wang, YP Timilsena, E Blanch… - Critical reviews in food …, 2019 - Taylor & Francis
Lactoferrin (LF) is a multifunctional protein occurring in many biological secretions including
milk. It possesses iron binding/transferring, antibacterial, antiviral, antifungal, anti …

Cancer stem cells: A review from origin to therapeutic implications

MR Atashzar, R Baharlou, J Karami… - Journal of cellular …, 2020 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

AO Elzoghby, MA Abdelmoneem, IA Hassanin… - Biomaterials, 2020 - Elsevier
Recent progress in protein-based nanomedicine, inspired by the success of Abraxane®
albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of …

Lactoferrin's anti-cancer properties: Safety, selectivity, and wide range of action

A Cutone, L Rosa, G Ianiro, MS Lepanto… - Biomolecules, 2020 - mdpi.com
Despite recent advances in cancer therapy, current treatments, including radiotherapy,
chemotherapy, and immunotherapy, although beneficial, present attendant side effects and …

Novel peptide therapeutic approaches for cancer treatment

CM Li, P Haratipour, RG Lingeman, JJP Perry, L Gu… - Cells, 2021 - mdpi.com
Peptides are increasingly being developed for use as therapeutics to treat many ailments,
including cancer. Therapeutic peptides have the advantages of target specificity and low …

Nutraceutical and health-promoting potential of lactoferrin, an iron-binding protein in human and animal: current knowledge

MF Ashraf, D Zubair, MN Bashir, M Alagawany… - … Trace Element Research, 2024 - Springer
Lactoferrin is a natural cationic iron-binding glycoprotein of the transferrin family found in
bovine milk and other exocrine secretions, including lacrimal fluid, saliva, and bile …

[HTML][HTML] Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue …

F Li, T Jiang, Q Li, X Ling - American journal of cancer research, 2017 - ncbi.nlm.nih.gov
Camptothecin (CPT) was discovered from plant extracts more than 60 years ago. Since then,
only two CPT analogues (irinotecan and topotecan) have been approved for cancer …

Emerging importance of survivin in stem cells and cancer: the development of new cancer therapeutics

NM Warrier, P Agarwal, P Kumar - Stem Cell Reviews and Reports, 2020 - Springer
Survivin is one of the rare proteins that is differentially expressed in normal and cancer cells
and is directly or indirectly involved in numerous pathways required for tumor maintenance …

Hybrid protein-inorganic nanoparticles: from tumor-targeted drug delivery to cancer imaging

AO Elzoghby, AL Hemasa, MS Freag - Journal of Controlled Release, 2016 - Elsevier
Recently, a great interest has been paid to the development of hybrid protein-inorganic
nanoparticles (NPs) for drug delivery and cancer diagnostics in order to combine the merits …

Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions

JR Kanwar, K Roy, Y Patel, SF Zhou, MR Singh… - Molecules, 2015 - mdpi.com
Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have
numerous functions. Even though Lf was first isolated from milk, it is also found in most …