Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

The three ternary complex factors (TCFs) Elk-1, Net and Sap-1 form a subfamily of the E
twenty-six (Ets) domain transcription factors. Their characteristic property is the ability to form …

Genetically encoded photoswitches have enabled spatial and temporal control of cellular
events to achieve tailored functions in living cells, but their applications to probe the …

▪ Abstract Autoinhibitory domains are regions of proteins that negatively regulate the function
of other domains via intramolecular interactions. Autoinhibition is a potent regulatory …

Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA
binding domain, the ETS domain. Over 25 mammalian Ets family members control important …

The E26 transformation-specific (ETS) family of transcription factors is critical for
development, differentiation, proliferation and also has a role in apoptosis and tissue …

Chemokines are secreted into the tumor microenvironment by tumor-infiltrating inflammatory
cells as well as by tumor cells. Chemokine receptors mediate agonist-dependent cell …

Phosphorylation of transcription factors is a key link between cell signaling and the control of
gene expression. Here we report that phosphorylation regulates DNA binding of the Ets-1 …

Core-binding factor α2 (CBFα2; otherwise known as AML1 or PEBP2αB) is a DNA-binding
subunit in the family of core-binding factors (CBFs), heterodimeric transcription factors that …

Ets proteins are a family of transcription factors that regulate the expression of a myriad of
genes in a variety of tissues and cell types. This functional versatility emerges from their …