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The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Background Bronchiectasis is a heterogeneous, neglected disease with few multicentre
studies exploring the causes, severity, microbiology, and treatment of the disease across …

Bronchiectasis refers to both a clinical disease and a radiological appearance that has
multiple causes and can be associated with a range of conditions. Disease heterogeneity …

Rationale: Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic
subtypes have recently been described. Objectives: To use multiple datasets available …

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …

The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Background Patients with bronchiectasis have frequent exacerbations that are thought to be
related to neutrophilic inflammation. The activity and quantity of neutrophil serine proteases …

Background Bronchiectasis is a common but neglected chronic lung disease. Most
epidemiological data are limited to cohorts from Europe and the USA, with few data from low …