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Idiopathic pulmonary fibrosis: an update on pathogenesis
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy
Numerous agents targeting various phosphatidylinositol 3-kinase (PI3K) pathway
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …
[HTML][HTML] Myofibroblasts: function, formation, and scope of molecular therapies for skin fibrosis
Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …
Emerging role of immune cells as drivers of pulmonary fibrosis
The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …
other forms of interstitial lung disease, involves a complex interplay of various factors …
TGF-β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis
Z Ye, Y Hu - International journal of molecular …, 2021 - spandidos-publications.com
Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …
irreversible decline of lung function. Currently, there is no drug to successfully treat the …
Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects
Immunotherapy is improving the prognosis and survival of cancer patients, but despite
encouraging outcomes in different cancers, the majority of tumors are resistant to it, and the …
encouraging outcomes in different cancers, the majority of tumors are resistant to it, and the …
The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review
B Zhou, H Liu, F Xu, X Jia - Cell Communication and Signaling, 2024 - Springer
Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high
mortality rate. Patients with PF commonly experience a chronic dry cough and progressive …
mortality rate. Patients with PF commonly experience a chronic dry cough and progressive …
Fibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing
Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles
in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts …
in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts …
[HTML][HTML] Metabolites and immune response in tumor microenvironments
Simple Summary Cancer cells alter their metabolisms to support growth, thus causing micro-
and macronutrient changes in the metabolite profile that promote an immunosuppressive …
and macronutrient changes in the metabolite profile that promote an immunosuppressive …
Backstage players of fibrosis: NOX4, mTOR, HDAC, and S1P; companions of TGF-β
The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …
deposition, leading to disruption of tissue architecture and eventually loss of function; …