Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental
processes; in consequence, PPIs are associated with several pathological conditions …

Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has
been shown to be a key mediator in autoimmune diseases such as rheumatoid arthritis and …

Fluoroquinolone antibiotics (FQs) have been used worldwide due to their extended
antimicrobial spectrum. However, the overuse of FQs leads to frequent detection in the …

Monoclonal antibodies (mAbs) blocking the PD-1/PD-L1 interface have shown remarkable
success in treating malignancies, but they may also initiate lethal immune-related adverse …

In this study we explored the molecular mechanism of RdRp (Non-Structural Protein,
NSP12) interaction with its co-factors NSP7 and NSP8 which is the main toolbox for RNA …

Drug repurposing is a creative and resourceful approach to increase the number of
therapies by exploiting available and approved drugs. However, identifying new protein …

The interaction of exoribonuclease (ExoN) nonstructural protein (NSP14) with NSP10 co-
factors is crucial for high-fidelity proofreading activity of coronavirus replication and …

Steroidogenesis is strictly regulated at multiple levels, as produced steroid hormones are
crucial to maintain physiological functions. Cytochrome P450 enzymes are key players in …

Although protein–protein interactions (PPIs) have emerged as the basis of potential new
therapeutic approaches, targeting intracellular PPIs with small molecule inhibitors is …