Open challenges for microbial network construction and analysis

K Faust - The ISME Journal, 2021 - academic.oup.com
Microbial network construction is a popular explorative data analysis technique in
microbiome research. Although a large number of microbial network construction tools has …

From hairballs to hypotheses–biological insights from microbial networks

L Röttjers, K Faust - FEMS microbiology reviews, 2018 - academic.oup.com
Microbial networks are an increasingly popular tool to investigate microbial community
structure, as they integrate multiple types of information and may represent systems-level …

A quantitative framework reveals ecological drivers of grassland microbial community assembly in response to warming

D Ning, M Yuan, L Wu, Y Zhang, X Guo, X Zhou… - Nature …, 2020 - nature.com
Unraveling the drivers controlling community assembly is a central issue in ecology.
Although it is generally accepted that selection, dispersal, diversification and drift are major …

Benchmarking algorithms for gene regulatory network inference from single-cell transcriptomic data

A Pratapa, AP Jalihal, JN Law, A Bharadwaj… - Nature methods, 2020 - nature.com
We present a systematic evaluation of state-of-the-art algorithms for inferring gene
regulatory networks from single-cell transcriptional data. As the ground truth for assessing …

Benchmark and integration of resources for the estimation of human transcription factor activities

L Garcia-Alonso, CH Holland, MM Ibrahim… - Genome …, 2019 - genome.cshlp.org
The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …

Disentangling direct from indirect relationships in association networks

N **ao, A Zhou, ML Kempher… - Proceedings of the …, 2022 - National Acad Sciences
Networks are vital tools for understanding and modeling interactions in complex systems in
science and engineering, and direct and indirect interactions are pervasive in all types of …

Gene regulatory network inference from single-cell data using multivariate information measures

TE Chan, MPH Stumpf, AC Babtie - Cell systems, 2017 - cell.com
While single-cell gene expression experiments present new challenges for data processing,
the cell-to-cell variability observed also reveals statistical relationships that can be used by …

Big data analytics in healthcare

A Belle, R Thiagarajan… - BioMed research …, 2015 - Wiley Online Library
The rapidly expanding field of big data analytics has started to play a pivotal role in the
evolution of healthcare practices and research. It has provided tools to accumulate, manage …

Wisdom of crowds for robust gene network inference

D Marbach, JC Costello, R Küffner, NM Vega, RJ Prill… - Nature …, 2012 - nature.com
Reconstructing gene regulatory networks from high-throughput data is a long-standing
challenge. Through the Dialogue on Reverse Engineering Assessment and Methods …

Molecular networks in Network Medicine: Development and applications

EK Silverman, HHHW Schmidt… - … Systems Biology and …, 2020 - Wiley Online Library
Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …