Open challenges for microbial network construction and analysis
K Faust - The ISME Journal, 2021 - academic.oup.com
Microbial network construction is a popular explorative data analysis technique in
microbiome research. Although a large number of microbial network construction tools has …
microbiome research. Although a large number of microbial network construction tools has …
From hairballs to hypotheses–biological insights from microbial networks
L Röttjers, K Faust - FEMS microbiology reviews, 2018 - academic.oup.com
Microbial networks are an increasingly popular tool to investigate microbial community
structure, as they integrate multiple types of information and may represent systems-level …
structure, as they integrate multiple types of information and may represent systems-level …
A quantitative framework reveals ecological drivers of grassland microbial community assembly in response to warming
Unraveling the drivers controlling community assembly is a central issue in ecology.
Although it is generally accepted that selection, dispersal, diversification and drift are major …
Although it is generally accepted that selection, dispersal, diversification and drift are major …
Benchmarking algorithms for gene regulatory network inference from single-cell transcriptomic data
We present a systematic evaluation of state-of-the-art algorithms for inferring gene
regulatory networks from single-cell transcriptional data. As the ground truth for assessing …
regulatory networks from single-cell transcriptional data. As the ground truth for assessing …
Benchmark and integration of resources for the estimation of human transcription factor activities
The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …
Disentangling direct from indirect relationships in association networks
Networks are vital tools for understanding and modeling interactions in complex systems in
science and engineering, and direct and indirect interactions are pervasive in all types of …
science and engineering, and direct and indirect interactions are pervasive in all types of …
Gene regulatory network inference from single-cell data using multivariate information measures
While single-cell gene expression experiments present new challenges for data processing,
the cell-to-cell variability observed also reveals statistical relationships that can be used by …
the cell-to-cell variability observed also reveals statistical relationships that can be used by …
Big data analytics in healthcare
A Belle, R Thiagarajan… - BioMed research …, 2015 - Wiley Online Library
The rapidly expanding field of big data analytics has started to play a pivotal role in the
evolution of healthcare practices and research. It has provided tools to accumulate, manage …
evolution of healthcare practices and research. It has provided tools to accumulate, manage …
Wisdom of crowds for robust gene network inference
Reconstructing gene regulatory networks from high-throughput data is a long-standing
challenge. Through the Dialogue on Reverse Engineering Assessment and Methods …
challenge. Through the Dialogue on Reverse Engineering Assessment and Methods …
Molecular networks in Network Medicine: Development and applications
EK Silverman, HHHW Schmidt… - … Systems Biology and …, 2020 - Wiley Online Library
Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
pathogenesis. Many different analytical methods have been used to infer relevant molecular …