Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …

Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Z Lai, X Yuan, H Chen, Y Zhu, N Dong, A Shan - Biotechnology Advances, 2022 - Elsevier
Due to the alarming develo** rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …

Self-assembling peptide dendron nanoparticles with high stability and a multimodal antimicrobial mechanism of action

Z Lai, Q Jian, G Li, C Shao, Y Zhu, X Yuan, H Chen… - ACS …, 2021 - ACS Publications
Self-assembling nanometer-scale structured peptide polymers and peptide dendrimers have
shown promise in biomedical applications due to their versatile properties and easy …

Enhancing the stability of antimicrobial peptides: From design strategies to biomedical applications

S Xu, P Tan, Q Tang, T Wang, Y Ding, H Fu… - Chemical Engineering …, 2023 - Elsevier
Antimicrobial peptides (AMPs) offer unique advantages due to their membrane-active
antimicrobial mechanisms, which reduce the likelihood of resistance development …

Design of Proteolytic-Resistant Antifungal Peptides by Utilizing Minimum d-Amino Acid Ratios

Z Lai, X Yuan, W Chen, H Chen, B Li, Z Bi… - Journal of Medicinal …, 2024 - ACS Publications
Antifungal peptides are an appealing alternative to standard antifungal medicines due to
their unique mechanism of action and low-level resistance. However, their susceptibility to …

Hydrophobic modification improves the delivery of cell-penetrating peptides to eliminate intracellular pathogens in animals

Q Tang, P Tan, Z Dai, T Wang, S Xu, Y Ding, J **… - Acta Biomaterialia, 2023 - Elsevier
Infections induced by intracellular pathogens are difficult to eradicate due to poor
penetration of antimicrobials into cell membranes. It is of great importance to develop a new …

Rational avoidance of protease cleavage sites and symmetrical end-tagging significantly enhances the stability and therapeutic potential of antimicrobial peptides

Y Zhu, C Shao, G Li, Z Lai, P Tan, Q Jian… - Journal of medicinal …, 2020 - ACS Publications
Antimicrobial peptides (AMPs) are expected to solve problem of antibiotic resistance
because of their distinctive nonspecific membrane-disruptive mechanism. However, clinical …

Manipulation of hydrophobic motifs and optimization of sequence patterns to design high stability peptides against piglet bacterial infections

P Tan, Z Sun, Q Tang, S Xu, T Wang, Y Ding, H Fu… - Nano Today, 2023 - Elsevier
The risk of resistance to traditional antibiotics has led to a shift in attention to novel
antimicrobial functional biomaterials. Antimicrobial peptides (AMPs) have been recognized …

Self-assembly of antimicrobial peptide-based micelles breaks the limitation of trypsin

W Yu, Y Sun, W Li, X Guo, X Liu, W Wu… - … Applied Materials & …, 2022 - ACS Publications
Targeting the limitation of antimicrobial peptides (AMPs) application in vivo, self-assembled
AMPs library with specific nanostructures is expected to gradually overtake monomer AMPs …

An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro …

J Zhou, L Zhang, Y He, K Liu, F Zhang, H Zhang… - European Journal of …, 2021 - Elsevier
Due to the threat of escalating multi-drug resistant gram-negative bacteria to human health
and life, novel antimicrobial agents against gram-negative pathogens are urgently needed …