Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Transforming growth factor β (TGF-β) is a key cytokine regulating the development,
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …

Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg)
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …

Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …

Severe trauma is an intractable problem in healthcare. Patients have a widespread immune
system response that is complex and vital to survival. Excessive inflammatory response is …

Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Regulatory T cells (Treg) are conventionally viewed as suppressors of endogenous and
therapy-induced antitumor immunity; however, their role in modulating responses to immune …

Allergic diseases are a global health challenge. Individuals harboring loss-of-function
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …