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The critical role of RNA processing and degradation in the control of gene expression
The continuous degradation and synthesis of prokaryotic mRNAs not only give rise to the
metabolic changes that are required as cells grow and divide but also rapid adaptation to …
metabolic changes that are required as cells grow and divide but also rapid adaptation to …
The tmRNA system for translational surveillance and ribosome rescue
SD Moore, RT Sauer - Annu. Rev. Biochem., 2007 - annualreviews.org
The tmRNA system performs translational surveillance and ribosome rescue in all
eubacteria and some eukaryotic organelles. This system intervenes when ribosomes read to …
eubacteria and some eukaryotic organelles. This system intervenes when ribosomes read to …
The role of RNases in the regulation of small RNAs
Highlights•Bacterial RNases control sRNA-mediated negative and positive
regulation.•RNase III can simultaneously cleave the sRNAs and their respective mRNA …
regulation.•RNase III can simultaneously cleave the sRNAs and their respective mRNA …
RNase R degrades non‐stop mRNAs selectively in an SmpB‐tmRNA‐dependent manner
The SmpB‐tmRNA‐mediated trans‐translation system has two well‐established activities:
rescuing ribosomes stalled on aberrant mRNAs and marking the associated protein …
rescuing ribosomes stalled on aberrant mRNAs and marking the associated protein …
tmRNA-mediated trans-translation as the major ribosome rescue system in a bacterial cell
Transfer messenger RNA (tmRNA; also known as 10Sa RNA or SsrA RNA) is a small RNA
molecule that is conserved among bacteria. It has structural and functional similarities to …
molecule that is conserved among bacteria. It has structural and functional similarities to …
The role of 3′–5′ exoribonucleases in RNA degradation
RNA degradation is a major process controlling RNA levels and plays a central role in cell
metabolism. From the labile messenger RNA to the more stable noncoding RNAs (mostly …
metabolism. From the labile messenger RNA to the more stable noncoding RNAs (mostly …
An RNA degradosome assembly in Caulobacter crescentus
In many bacterial species, the multi-enzyme RNA degradosome assembly makes key
contributions to RNA metabolism. Powering the turnover of RNA and the processing of …
contributions to RNA metabolism. Powering the turnover of RNA and the processing of …
An overview of the bacterial SsrA system modulating intracellular protein levels and activities
In bacteria, the truncated forms of mRNAs, which usually lack a stop codon, are occasionally
generated by premature termination of gene transcription and/or endo-or exonucleolytic …
generated by premature termination of gene transcription and/or endo-or exonucleolytic …
Trans-Translation: The tmRNA-Mediated Surveillance Mechanism for Ribosome Rescue, Directed Protein Degradation, and Nonstop mRNA Decay
The accurate flow of genetic information from DNA to RNA to protein is essential for all living
organisms. An astonishing array of quality-assurance mechanisms have evolved to ensure …
organisms. An astonishing array of quality-assurance mechanisms have evolved to ensure …
Elevation of RNase R in response to multiple stress conditions
C Chen, MP Deutscher - Journal of Biological Chemistry, 2005 - jbc.org
Cells respond to adverse environmental conditions by synthesizing new proteins or
elevating the levels of pre-existing ones that are needed to cope with the particular stress …
elevating the levels of pre-existing ones that are needed to cope with the particular stress …