The ancillary effects of nanoparticles and their implications for nanomedicine

EP Stater, AY Sonay, C Hart, J Grimm - Nature Nanotechnology, 2021 - nature.com
Nanoparticles are often engineered as a scaffolding system to combine targeting, imaging
and/or therapeutic moieties into a unitary agent. However, mostly overlooked, the …

Novel approaches to immunomodulation for solid organ transplantation

I Husain, X Luo - Annual Review of Medicine, 2024 - annualreviews.org
Despite significant advances in the field of transplantation in the past two decades, current
clinically available therapeutic options for immunomodulation remain fairly limited. The …

Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

JM Gammon, ST Carey, V Saxena, HB Eppler… - Nature …, 2023 - nature.com
Antigen-specific tolerance is a key goal of experimental immunotherapies for autoimmune
disease and allograft rejection. This outcome could selectively inhibit detrimental …

Polymer nanotherapeutics to correct autoimmunity

T Su, X Feng, J Yang, W Xu, T Liu, M Zhang… - Journal of Controlled …, 2022 - Elsevier
The immune system maintains homeostasis and protects the body from pathogens, mutated
cells, and other harmful substances. When immune homeostasis is disrupted, excessive …

Biomaterial strategies for selective immune tolerance: advances and gaps

ST Carey, C Bridgeman, CM Jewell - Advanced Science, 2023 - Wiley Online Library
Autoimmunity and allergies affect a large number of people across the globe. Current
approaches to these diseases target cell types and pathways that drive disease, but these …

Cargo-less nanoparticles program innate immune cell responses to toll-like receptor activation

LM Casey, S Kakade, JT Decker, JA Rose, K Deans… - Biomaterials, 2019 - Elsevier
Develo** biomaterials to control the responsiveness of innate immune cells represents a
clinically relevant approach to treat diseases with an underlying inflammatory basis, such as …

Nanotechnology applications in transplantation medicine

CG Yao, PN Martins - Transplantation, 2020 - journals.lww.com
A recent technological advance that shows promise for applications in health care, including
transplantation medicine, is the implementation of nanoparticles. Nanoparticles can be …

Nanoparticle platforms for antigen-specific immune tolerance

EB Thorp, C Boada, C Jarbath, X Luo - Frontiers in immunology, 2020 - frontiersin.org
Innovative approaches in nanoparticle design have facilitated the creation of new
formulations of nanoparticles that are capable of selectively calibrating the immune …

Engineering immunity using metabolically active polymeric nanoparticles

KV Griffin, MN Saunders, CA Lyssiotis, LD Shea - Trends in Biotechnology, 2024 - cell.com
Immune system functions play crucial roles in both health and disease, and these functions
are regulated by their metabolic programming. The field of immune engineering has …

Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery

JGN Solidum, JA Ceriales, EP Ong, EDB Ornos… - Maxillofacial Plastic and …, 2023 - Springer
Background Nanotechnology and nanomedicine are rising novel fields in plastic and
reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative …