The spatio-temporal timing of the last round of mitosis, followed by the migration of
neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is …

The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

Medulloblastomas are the most common malignant brain tumours in children. Identifying
and understanding the genetic events that drive these tumours is critical for the development …

Transcription factors are regulatory proteins that either activate or repress the transcription of
genes via binding to DNA regulatory sequences and regulating recruitment of transcriptional …

Multipotential mesenchymal stem cells (MSCs) are able to differentiate along several known
lineages and have been shown to be efficacious for in vivo wound repair. The growth and …

Human mesenchymal stem cells (hMSCs) can home to tumor sites and inhibit the growth of
tumor cells. Little is known about the underlying molecular mechanisms that link hMSCs to …

Solving the biological roles of covalent histone modifications, including monoubiquitination
of histone H2A, and the molecular mechanisms by which these modifications regulate …

There is widespread interest in defining factors and mechanisms that stimulate proliferation
of pancreatic islet cells. Wnt signaling is an important regulator of organ growth and cell …

The APC tumor suppressor controls the stability and nuclear export of β-catenin (β-cat), a
transcriptional coactivator of LEF-1/TCF HMG proteins in the Wnt/Wg signaling pathway. We …

Wingless (Wnt)/β-catenin signaling plays an essential role during normal development, is a
critical regulator of stem cells, and has been associated with cancer in many tissues. Here …