Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Virotherapy is currently undergoing a renaissance, based on our improved understanding of
virus biology and genetics and our better knowledge of many different types of cancer …

We hypothesized that the combination of oncolytic virotherapy with immune checkpoint
modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity …

Oncolytic viruses (OVs) are engineered and/or evolved to propagate selectively in
cancerous tissues. They have a dual mechanism of action; direct killing of infected cancer …

Measles virus (MeV) preferentially replicates in malignant cells, leading to tumor lysis and
priming of antitumor immunity. Live attenuated MeV vaccine strains are therefore under …

Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially
infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically …

Oncolytic virotherapeutic agents are likely to become serious contenders in cancer
treatment. The vaccine strain of measles virus is an agent with an impressive range of …

Oncolytic viruses (OV) are promising treatments for cancer, with several currently
undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested …

Metastatic cancer remains an incurable disease in the majority of cases and thus novel
treatment strategies such as oncolytic virotherapy are rapidly advancing toward clinical use …

Targeted therapy of cancer using oncolytic viruses has generated much interest over the
past few years in the light of the limited efficacy and side effects of standard cancer …