Neural tube defects: a review of global prevalence, causes, and primary prevention

V Kancherla - Child's Nervous System, 2023 - Springer
Neural tube defects (NTDs) are common birth defects and contribute to life-long disabilities,
high medical care costs, and perinatal and child mortality. This review is a primer on …

Environmental exposures and adverse pregnancy outcomes in Ethiopia: a systematic review and meta-analysis

H Demelash Enyew, BG Bogale, AB Hailu, ST Mereta - Plos one, 2023 - journals.plos.org
Background Maternal exposures to environmental hazards during pregnancy are key
determinants of birth outcomes that affect health, cognitive and economic status later in life …

Overview of neural tube defects: gene–environment interactions, preventative approaches and future perspectives

J Isaković, I Šimunić, D Jagečić, V Hribljan, D Mitrečić - Biomedicines, 2022 - mdpi.com
Neural tube defects (NTDs) are the second most common congenital malformations of
humans, characterized by impaired development of the central nervous system. Even …

Birth prevalence and determinants of neural tube defects among newborns in Ethiopia: A systematic review and meta-analysis

BM Gebremariam, D Hailu, BJ Stoecker, A Mulugeta - PloS one, 2025 - journals.plos.org
Background Neural tube defects (NTDs) are complex multifactorial disorders in the
neurulation of the brain and spinal cord that develop in humans between 21 and 28 days of …

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

N Tesfay, G Hailu, M Habtetsion, F Woldeyohannes - BMJ open, 2023 - bmjopen.bmj.com
Objective This study aims to estimate the prevalence of neural tube defects (NTDs) and to
identify potential risk factors in the Ethiopian context. Study design Systematic review and …

A quest for genetic causes underlying signaling pathways associated with neural tube defects

S Rai, L Leydier, S Sharma, J Katwala… - Frontiers in Pediatrics, 2023 - frontiersin.org
Neural tube defects (NTDs) are serious congenital deformities of the nervous system that
occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors …

Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta‐Analysis

R Wakoya, M Afework - International Journal of Pediatrics, 2023 - Wiley Online Library
Background. Neural tube defects are a type of congenital anomaly caused by an
abnormality in the development of the brain and spinal cord during embryogenesis. They …

Evaluation of neural tube defects from 2014 to 2019 in Turkey

N Çaylan, SS Yalçin, B Tezel, Ş Aydin, O Üner… - BMC Pregnancy and …, 2022 - Springer
Objective The aim of this study is to determine the frequency of neural tube defects (NTDs)
and to examine the epidemiological characteristics of NTD related deaths in Turkey …

Abnormal methylation caused by folic acid deficiency in neural tube defects

R Cao, J **e, L Zhang - Open Life Sciences, 2022 - degruyter.com
Neural tube closure disorders, including anencephaly, spina bifida, and encephalocele,
cause neural tube defects (NTDs). This congenital disability remained not only a major …

Folic acid supplementation during preconception period in sub-Saharan African countries: A systematic review and meta-analysis

MN Aweke, EA Fentie, MC Agimas, LD Baffa… - PloS one, 2025 - journals.plos.org
Introduction Neural tube defects (NTDs) are serious congenital anomalies of the central
nervous system caused by disruptions in early embryonic development. The prevalence is …