The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …

The ability of signalling proteins to traverse tissues containing tightly packed cells is of
fundamental importance for cell specification and tissue development; however, how this is …

The zebrafish research community is celebrating! The zebrafish genome has recently been
sequenced, the Zebrafish Mutation Project (launched by the Wellcome Trust Sanger …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

We present simple and efficient methods for creating heritable modifications of the zebrafish
genome. Precisely modified alleles are generated by homologous recombination between …

Defective coronary network function and insufficient blood supply are both cause and
consequence of myocardial infarction. Efficient revascularization after infarction is essential …

The neural crest (NC) is a major contributor to the vertebrate craniofacial skeleton, detailed
in model organisms through embryological and genetic approaches, most notably in chick …

Damage-induced fibrotic scarring limits tissue regeneration in mammals and is a leading
cause of morbidity. In contrast, species like zebrafish can regenerate damaged tissues …