Functional genomics of PCOS: from GWAS to molecular mechanisms
Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by increased
ovarian androgen biosynthesis, anovulation, and infertility. PCOS has a strong heritable …
ovarian androgen biosynthesis, anovulation, and infertility. PCOS has a strong heritable …
A comprehensive overview of common polymorphic variants in genes related to polycystic ovary syndrome
T Castillo-Higuera, MC Alarcón-Granados… - Reproductive …, 2021 - Springer
Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic
disorders in women of reproductive age. It is characterized by an increase in the …
disorders in women of reproductive age. It is characterized by an increase in the …
Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta‐analysis
X Shi, X **e, Y Jia, S Li - Journal of Obstetrics and Gynaecology …, 2016 - Wiley Online Library
Aim Recently, the roles of insulin receptor (INSR) and insulin receptor substrate (IRS)
polymorphisms in polycystic ovary syndrome (PCOS) have been extensively studied, with …
polymorphisms in polycystic ovary syndrome (PCOS) have been extensively studied, with …
[HTML][HTML] Fetal programming of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects up to 6.8%
of reproductive age women. Experimental research and clinical observations suggest that …
of reproductive age women. Experimental research and clinical observations suggest that …
Clinical management of androgen excess and defect in women
Introduction Hyperandrogenism and hypoandrogenism are complex disorders involving
multiple-organ systems. While androgen excess is a well-characterized condition, androgen …
multiple-organ systems. While androgen excess is a well-characterized condition, androgen …
Single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 genes in the pathogenesis of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common and a complex female endocrine
disorder, and is one of the leading cause of female infertility. Here, we aimed to investigate …
disorder, and is one of the leading cause of female infertility. Here, we aimed to investigate …
The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate–Induced polycystic ovary …
Gingerol is the major pungent ingredient of ginger with anti-inflammatory and antioxidant
properties. In this study, we evaluate the effects of 6-gingerol on the biochemical parameters …
properties. In this study, we evaluate the effects of 6-gingerol on the biochemical parameters …
Replication study and meta-analysis of selected genetic variants and polycystic ovary syndrome susceptibility in Asian population
P Wan, L Meng, C Huang, B Dai, Y **, L Chai… - Journal of Assisted …, 2021 - Springer
Purpose Polycystic ovary syndrome (PCOS) is a highly complex disorder influenced by
genetic and environmental factors. Previous association studies have identified multiple …
genetic and environmental factors. Previous association studies have identified multiple …
The Association between Polymorphism of INSR and Polycystic Ovary Syndrome: A Meta-Analysis
C Feng, PP Lv, TT Yu, M **, JM Shen, X Wang… - International journal of …, 2015 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorder.
The genetic background is believed to play a crucial role in the pathogenesis of PCOS. In …
The genetic background is believed to play a crucial role in the pathogenesis of PCOS. In …
APPL1 as an important regulator of insulin and adiponectin‐signaling pathways in the PCOS: A narrative review
Adaptor protein containing a PH domain, PTB domain and leucine zipper motif 1 (APPL1)
plays a central role as the main contributing factor in the adiponectin and insulin signaling …
plays a central role as the main contributing factor in the adiponectin and insulin signaling …