Cannabidiol for neurodegenerative disorders: A comprehensive review

S Bhunia, N Kolishetti, AY Arias, A Vashist… - Frontiers in …, 2022 - frontiersin.org
Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …

Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease

D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

Hypoxia, oxidative stress, and inflammation: three faces of neurodegenerative diseases

A Merelli, M Repetto, A Lazarowski… - Journal of Alzheimer's …, 2021 - journals.sagepub.com
The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …

[HTML][HTML] Therapeutic potential of cannabis: a comprehensive review of current and future applications

ZJ Leinen, R Mohan, LS Premadasa, A Acharya… - Biomedicines, 2023 - mdpi.com
Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming
properties. Ancient civilizations like the Egyptians, Greeks, and Chinese medicines …

Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy

SN Rai, N Tiwari, P Singh, D Mishra, AK Singh… - Frontiers in …, 2021 - frontiersin.org
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Endocannabinoid system: chemical characteristics and biological activity

B Rezende, AKN Alencar, GF de Bem… - Pharmaceuticals, 2023 - mdpi.com
The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Modulation of oxidative stress and Neuroinflammation by Cannabidiol (CBD): promising targets for the treatment of Alzheimer's disease

JP Hickey, AE Collins, ML Nelson, H Chen… - Current Issues in …, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common form of dementia globally. Although the direct cause of AD remains under debate …

Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating …

M McDew-White, E Lee, LS Premadasa… - Journal of …, 2023 - Springer
Background Although the advent of combination anti-retroviral therapy (cART) has
transformed HIV into a manageable chronic disease, an estimated 30–50% of people living …

[HTML][HTML] Cannabis sativa and cannabidiol: a therapeutic strategy for the treatment of neurodegenerative diseases?

MB Viana, PEA Aquino, D Estadella… - Medical Cannabis and …, 2022 - karger.com
This work is a literature review, presenting the current state of the use of cannabinoids on
neurodegenerative diseases. The emphasis is on Parkinson's (PD) and Alzheimer's (AD) …

Novel cannabidiol− carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against …

X Jiang, Z Zhang, J Zuo, C Wu, L Zha, Y Xu… - European journal of …, 2021 - Elsevier
Cannabidiol (CBD) and rivastigmine have been launched as drugs for treating dementia
and cholinesterases (ChEs) are ideal drug targets. This study focused on develo** novel …