A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements
Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …
ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity
AJ Brownstein, M Veliova, R Acin-Perez… - Reviews in Endocrine …, 2022 - Springer
Obesity results from an imbalance in energy homeostasis, whereby excessive energy intake
exceeds caloric expenditure. Energy can be dissipated out of an organism by producing …
exceeds caloric expenditure. Energy can be dissipated out of an organism by producing …
Triglyceride cycling enables modification of stored fatty acids
K Wunderling, J Zurkovic, F Zink, L Kuerschner… - Nature …, 2023 - nature.com
Triglyceride cycling is the process of continuous degradation and re-synthesis of triglyceride
in cellular stores. We show in 3T3-L1 adipocytes that triglycerides are subject to rapid …
in cellular stores. We show in 3T3-L1 adipocytes that triglycerides are subject to rapid …
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis
Adaptive thermogenesis by brown adipose tissue (BAT) dissipates calories as heat, making
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …
[HTML][HTML] Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat
J Oeckl, P Janovska, K Adamcova, K Bardova… - Molecular …, 2022 - Elsevier
Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle
Summary Although uncoupling protein 1 (UCP1) is established as a major contributor to
adipose thermogenesis, recent data have illustrated an important role for alternative …
adipose thermogenesis, recent data have illustrated an important role for alternative …
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism
Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
Brown adipose tissue heterogeneity, energy metabolism, and beyond
Brown adipocyte in brown adipose tissue (BAT) specializes in expending energy through
non-shivering thermogenesis, a process that produces heat either by uncoupling protein 1 …
non-shivering thermogenesis, a process that produces heat either by uncoupling protein 1 …
The importance of mitochondrial pyruvate carrier in cancer cell metabolism and tumorigenesis
A Ruiz-Iglesias, S Mañes - Cancers, 2021 - mdpi.com
Simple Summary The characteristic metabolic hallmark of cancer cells is the massive
catabolism of glucose by glycolysis, even under aerobic conditions—the so-called Warburg …
catabolism of glucose by glycolysis, even under aerobic conditions—the so-called Warburg …
Basal re-esterification finetunes mitochondrial fatty acid utilization
Objective Emerging evidence suggest the existence of constant basal lipolysis and re-
esterification of a substantial fraction of thus liberated fatty acids. In stimulated lipolysis, the …
esterification of a substantial fraction of thus liberated fatty acids. In stimulated lipolysis, the …