Comparative analysis of protein surface hydrophobicity maps determined by sparse sampling INDUS and spatial aggregation propensity

I Sinha, S Garde, SM Cramer - The Journal of Physical Chemistry …, 2023 - ACS Publications
Protein surface hydrophobicity plays a central role in various biological processes such as
protein folding and aggregation, as well as in the design and manufacturing of …

Exploring preferred binding domains of IgG1 mAbs to multimodal adsorbents using a combined biophysics and simulation approach

K Dhingra, I Sinha, M Snyder, D Roush… - Biotechnology …, 2024 - Wiley Online Library
In this work, we employ a recently developed biophysical technique that uses
diethylpyrocarbonate (DEPC) covalent labeling and mass spectrometry for the identification …

Biophysical Tools to Study Preferred Binding Domains for Protein Interactions with Chromatographic Surfaces

K Dhingra - 2023 - search.proquest.com
Multimodal resins have proven to be quite successful in removing various process and
product related impurities from protein therapeutics due to their ability to bind through …