The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the
Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane …

Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger
RNA delivery technology. Here, to advance the identification of ionizable lipids beyond …

Mucus is a viscoelastic material with non-linear rheological properties such as a yield stress
of the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …

Asthma is an intractable disease involving the infiltration of inflammatory cells and mucus
plugging. Despite small molecular mucolytics having the ability to break the disulfide bonds …

Gastrointestinal (GI) mucus plays a pivotal role in the tissue homoeostasis and functionality
of the gut. However, due to the shortage of affordable, realistic in vitro GI models with a …

Airway mucus is essential for lung defense, but excessive mucus in asthma obstructs airflow,
leading to severe and potentially fatal outcomes. Current asthma treatments have minimal …

The respiratory tract of larger animals is cleared by swee** bundled strands along the
airway surface. These bundled strands can be millimetric in length and consist of MUC5B …

Mucociliary clearance is a critical defense mechanism for the lungs governed by regionally
coordinated epithelial cellular activities, including mucin secretion, cilia beating, and …

Rationale: MUC5AC (mucin 5AC, oligomeric gel-forming) and MUC5B (mucin 5B,
oligomeric gel-forming) are the predominant secreted polymeric mucins in mammalian …