Tracking neurons across days with high-density probes

EH van Beest, C Bimbard, JMJ Fabre, SW Dodgson… - Nature …, 2024‏ - nature.com
Neural activity spans multiple time scales, from milliseconds to months. Its evolution can be
recorded with chronic high-density arrays such as Neuropixels probes, which can measure …

Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior

A Oryshchuk, C Sourmpis, J Weverbergh, R Asri… - Cell Reports, 2024‏ - cell.com
Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the
encoding of task variables is distributed across areas or is more specifically represented in …

Mouse frontal cortex mediates additive multisensory decisions

P Coen, TPH Sit, MJ Wells, M Carandini, KD Harris - Neuron, 2023‏ - cell.com
The brain can combine auditory and visual information to localize objects. However, the
cortical substrates underlying audiovisual integration remain uncertain. Here, we show that …

Emergence of cortical network motifs for short-term memory during learning

XW Chia, JK Tan, LF Ang, T Kamigaki… - Nature …, 2023‏ - nature.com
Learning of adaptive behaviors requires the refinement of coordinated activity across
multiple brain regions. However, how neural communications develop during learning …

Cellular substrate of eligibility traces

L Caya-Bissonnette, R Naud, JC Beique - BioRxiv, 2023‏ - biorxiv.org
The ability of synapses to undergo associative, activity-dependent weight changes
constitutes a linchpin of current cellular models of learning and memory. It is, however …

Prefrontal cortex encodes behavior states decoupled from movement

IV Rautio, F Nevjen, I Hem, BA Dunn, JR Whitlock - bioRxiv, 2024‏ - biorxiv.org
Prefrontal cortex is often viewed as an extension of the motor system, but little is understood
of how it relates to natural motor behavior. We therefore tracked the kinematics of freely …

Sensory History Drives Adaptive Neural Geometry in LP/Pulvinar-Prefrontal Cortex Circuits

YN Leow, A Barlowe, C Luo, Y Osako, M Jazayeri… - bioRxiv, 2024‏ - biorxiv.org
Prior expectations guide attention and support perceptual filtering for efficient processing
during decision-making. Here we show that during a visual discrimination task, mice …

Dnmt1-deficiency in PV interneurons alters cortical circuit function and leads to depression-like behavior

J Linde, G Nabbefeld, S Graff, CB Yildiz, D Pensold… - bioRxiv, 2024‏ - biorxiv.org
Neuropsychiatric disorders, including major depressive disorder (MDD), are highly prevalent
in modern society, arising from a complex interplay of genetic and environmental factors …

The adolescent frontal cortex shows stronger population-level encoding of information than the adult during a putative sensitive period

ME Klinger, H Wang, LH Tai, AJ Qü, M Murphy… - bioRxiv, 2024‏ - biorxiv.org
Adolescence is considered to be a sensitive period for brain development, but it is not clear
how the neocortex functions differently at this stage. We hypothesized that if there is a …

Circuit-Level Dynamics of Slow Wave Activity and Propagation During the Awakening Process

A Pazienti, M Müller, CA Bosman, U Olcese, M Mattia - bioRxiv, 2024‏ - biorxiv.org
Slow-wave activity (SWA) is a hallmark of the loss of consciousness in non-REM sleep and
anesthesia. The mechanistic underpinnings of SWA, and its evolution when transitioning …