CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Astatine-211 (211At) has physical properties that make it one of the top candidates for use
as a radiation source for alpha particle-based radionuclide therapy, also referred to as …

In contrast to external high energy photon or proton therapy, targeted radionuclide therapy
(TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and …

This article presents a general discussion on what has been achieved so far and on the
possible future developments of targeted alpha (α)-particle therapy (TAT). Clinical …

Radioisotopes of elements from all parts of the periodic table find both clinical and research
applications in radionuclide molecular imaging and therapy (nuclear medicine). This article …

Purpose Exosomes are small (30-to 100-nm) vesicles secreted by all cell types in culture
and found in most body fluids. A mean of 1 mL of blood serum, derived from healthy donors …

Radiation therapy (RT), including external beam radiotherapy (EBRT) and internal
radioisotope therapy (RIT), has been an indispensable strategy for cancer therapy in clinical …

Bioorthogonal click chemistry—employing antibody-conjugated trans-cyclooctenes (TCO)
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …

The pretargeting system based on the inverse electron demand Diels-Alder reaction
(IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable …