In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Recent advances in iron metabolism have stimulated new interest in iron deficiency (ID) and
its anemia (IDA), common conditions worldwide. Absolute ID/IDA, ie the decrease of total …

Disruptions in iron homeostasis from both iron deficiency and overload account for some of
the most common human diseases. Iron metabolism is balanced by two regulatory systems …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Iron is a micronutrient essential for cellular energy and metabolism, necessary for
maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the
expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism …

Abstract α-Enolase 1 (ENO1) is a critical glycolytic enzyme whose aberrant expression
drives the pathogenesis of various cancers. ENO1 has been indicated as having additional …