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[HTML][HTML] Bio-oriented synthesis of novel (S)-flurbiprofen clubbed hydrazone schiff's bases for diabetic management: In vitro and in silico studies
A new series of (S)-flurbiprofen derivatives 4a–4p and 5a–5n were synthesized with different
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …
Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study
Abstract Background Thiazole-based Schiff base compounds display significant
pharmacological potential with an ability to modulate the activity of many enzymes involved …
pharmacological potential with an ability to modulate the activity of many enzymes involved …
Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
In an effort to design and synthesize a new class of α-glucosidase inhibitor, we synthesized
benzothiazole hybrid having benzohydrazide moiety (5). Compound 5 was reacted with …
benzothiazole hybrid having benzohydrazide moiety (5). Compound 5 was reacted with …
Synthesis and radical scavenging activity of new phenolic hydrazone/hydrazide derivatives: Experimental and theoretical studies
Hydrazone and hydrazone-hydrazide-based compounds represent important classes of
compounds that continue to attract increasing interest due to their diverse pharmacological …
compounds that continue to attract increasing interest due to their diverse pharmacological …
[HTML][HTML] Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity
In an effort to develop new antibacterial drugs, some novel bisindolylmethane derivatives
containing Schiff base moieties were prepared and screened for their antibacterial activity …
containing Schiff base moieties were prepared and screened for their antibacterial activity …
Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies
We synthesized a series of novel 5–24 derivatives of oxindole. The synthesis started from 5-
chlorooxindole, which was condensed with methyl 4-carboxybezoate and result in the …
chlorooxindole, which was condensed with methyl 4-carboxybezoate and result in the …
2-Hydroxy-N′-((Thiophene-2-yl)methylene)benzohydrazide: Ultrasound-Assisted Synthesis and Corrosion Inhibition Study
2-Hydroxy-N′-((thiophene-2-yl) methylene) benzohydrazide (HTMBH) was synthesized by
conventional method as well as by ultrasonication (US). The ultrasound-assisted synthesis …
conventional method as well as by ultrasonication (US). The ultrasound-assisted synthesis …
Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative …
New benzofuranhydrazones 3–12 were easily prepared and assayed for their radical-
scavenging ability. Hydrazones 3–12 showed different extent antioxidant activity in DPPH …
scavenging ability. Hydrazones 3–12 showed different extent antioxidant activity in DPPH …
Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene-and pyrene-based Schiff base derivatives
Schiff base derivatives with anthracene-and pyrene-based units, A1-A6 and P1-P6 were
synthesized (89%-99% yields). Schiff base derivatives were designed to possess an …
synthesized (89%-99% yields). Schiff base derivatives were designed to possess an …
Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential
Compounds 1–30 showed varying degree of α-glucosidase inhibition with IC 50 values
ranging between 187 and 420 μ M. Compounds 1, 2, 3, 6, 8, 12, and 4 (IC 50= 187.7±3.05 …
ranging between 187 and 420 μ M. Compounds 1, 2, 3, 6, 8, 12, and 4 (IC 50= 187.7±3.05 …