Immunization is a cornerstone of public health policy and is demonstrably highly cost-
effective when used to protect child health. Although it could be argued that immunology has …

In the past few years, our understanding of immunological memory has evolved remarkably
due to a growing body of new knowledge in innate immune memory and immunity …

Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …

The tuberculosis (TB) vaccine Bacillus Calmette‐Guérin (BCG) was introduced 100 years
ago, but as it provides insufficient protection against TB disease, especially in adults, new …

Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …

Background The prevalence of tuberculosis among men who work in the gold mines of
South Africa is among the highest in the world, but a fraction of miners demonstrate …

Background Some individuals, even when heavily exposed to an infectious tuberculosis
patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early …

Background A proportion of tuberculosis (TB) case contacts do not become infected, even
when heavily exposed. We studied the innate immune responses of TB case contacts to …

Globally, it is estimated that one-quarter of the world's population is latently infected with
Mycobacterium tuberculosis (Mtb), also known as latent tuberculosis infection (LTBI) …

Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis (TB), is
responsible for millions of infections and deaths annually. Decades of TB vaccine …