Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

The necessity of disease models for bone/cartilage related disorders is well-recognized, but
the barrier between ex-vivo cell culture, animal models and the real human body has been …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …

Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Microengineered systems provide an in vitro strategy to explore the variability of individual
patient response to tissue engineering products, since they prefer the use of primary cell …

Bone metastasis is a common, yet serious, complication of breast cancer. Breast cancer
cells that extravasate from blood vessels to the bone devastate bone quality by interacting …

Mechanobiology-on-a-chip is a growing field focusing on how mechanical inputs modulate
physico-chemical output in microphysiological systems. It is well known that biomechanical …

In bone tissue engineering (TE) and regeneration, miniaturized,(sub) millimeter-sized bone
models have become a popular trend since they bring about physiological biomimicry …