The genetics of Parkinson disease
H Deng, P Wang, J Jankovic - Ageing research reviews, 2018 - Elsevier
About 15% of patients with Parkinson disease (PD) have family history and 5–10% have a
monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 …
monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 …
Epidemiology and etiology of Parkinson's disease: a review of the evidence
The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …
genetic and environmental factors. Incidence and prevalence estimates vary to a large …
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
We have previously linked families with autosomal-dominant, late-onset parkinsonism to
chromosome 12p11. 2-q13. 1 (PARK8). By high-resolution recombination map** and …
chromosome 12p11. 2-q13. 1 (PARK8). By high-resolution recombination map** and …
Alzheimer's disease and Parkinson's disease
RL Nussbaum, CE Ellis - New england journal of medicine, 2003 - Mass Medical Soc
Although most cases of Alzheimer's and Parkinson's disease are sporadic, some cases are
clearly familial. This review, part of the Genomic Medicine series, examines the genetics of …
clearly familial. This review, part of the Genomic Medicine series, examines the genetics of …
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …
compacta and subsequent reduction of dopamine levels in striatum are associated with …
Molecular pathways of neurodegeneration in Parkinson's disease
Parkinson's disease (PD) is a complex disorder with many different causes, yet they may
intersect in common pathways, raising the possibility that neuroprotective agents may have …
intersect in common pathways, raising the possibility that neuroprotective agents may have …
Molecular pathophysiology of Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …
Parkinson's disease: from monogenic forms to genetic susceptibility factors
S Lesage, A Brice - Human molecular genetics, 2009 - academic.oup.com
Research in Parkinson's disease (PD) genetics has been extremely prolific over the past
decade. More than 13 loci and 9 genes have been identified, but their implication in PD is …
decade. More than 13 loci and 9 genes have been identified, but their implication in PD is …
Parkinson's disease: genetics and pathogenesis
Recent investigation into the mechanisms of Parkinson's disease (PD) has generated
remarkable insight while simultaneously challenging traditional conceptual frameworks …
remarkable insight while simultaneously challenging traditional conceptual frameworks …
Genetics of Parkinson disease: paradigm shifts and future prospects
MJ Farrer - Nature Reviews Genetics, 2006 - nature.com
Parkinson disease is a complex, multifactorial neurodegenerative disease. Although a
heritable basis was originally thought unlikely, recent studies have implicated several genes …
heritable basis was originally thought unlikely, recent studies have implicated several genes …